NUCLEOFILL STRONG PLUS 1x2 ml – Advanced Polynucleotide Biostimulation for Mature & Photoaged Skin
NUCLEOFILL STRONG PLUS 1x2 ml is a next-generation polynucleotide-based bioregenerative injectable from Promoitalia Laboratories (Italy). It delivers deep dermal renewal, hydration, and firming, created for mature, lax, or photoaged skin needing structural restoration and long-term improvement.
Previously known as Nucleofill Age 2.5%.
Product Overview
Formulated with 2.5% highly purified polynucleotides (PN-HPT™ technology), NUCLEOFILL STRONG PLUS acts on three biological fronts—cell stimulation, antioxidant defense, and deep hydration—to enhance fibroblast activity, promote new collagen and elastin, and reinforce the dermal matrix for better elasticity, density, and radiance.
Composition & Technology
Active ingredient: Polynucleotides 2.5% (high-purity PN-HPT™)
pH: ~ 7.0
Viscosity: Optimized for dense dermal applications
Recommended delivery: 25G cannula or 30G needle
Mechanism (Triple Action):
Biostimulation – activates fibroblast receptors → collagen & elastin synthesis
Antioxidant defense – neutralizes free radicals, reduces photoaging damage
Deep hydration – long-lasting water binding in the ECM for firmness and plumpness
Content
1 x 2 ml prefilled sterile syringe
Product labels
Professional use instructions
Indications
Advanced skin aging and loss of firmness
Deep dehydration, dullness, and dermal thinning
Fine lines and textural decline
Treatment Areas
Face
Neck
Décolleté
Hands
Clinical Benefits
Stimulates dermal regeneration and collagen/elastin synthesis
Improves elasticity, tone, and dermal density
Provides deep, sustained hydration
Reduces oxidative stress and photoaging signs
Restores radiance and firmness with natural, non-volumizing results
Duration of Results
Typically 6–12 months, depending on age, skin status, and lifestyle. Maintenance every 6–9 months is recommended.
Application Protocol
Technique: Microinjections, linear retrograde, or multipoint technique
Sessions: 3–4 sessions, spaced 2–4 weeks apart
Aftercare: Mild erythema/edema possible; normal activities can usually resume the same day
Manufacturer & Regulatory Information
Manufacturer: Promoitalia Laboratories S.r.l. (Italy)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
