NUCLEOFILL STRONG 1x1.5 ml – Advanced Polynucleotide Biostimulation for Deep Skin Renewal
NUCLEOFILL STRONG 1x1.5 ml is an innovative biostimulation injectable from Promoitalia Laboratories (Italy), developed using high-purity polynucleotides to rejuvenate, hydrate, and firm the skin.
This treatment targets the deeper dermal layers to stimulate fibroblast activity, enhance collagen and elastin production, and protect against oxidative damage—restoring firmness, radiance, and hydration from within.
Product Overview
NUCLEOFILL STRONG acts through a Triple Action Mechanism—biostimulation, antioxidant protection, and deep hydration—to address visible signs of aging such as laxity, dullness, and fine lines.
It is suitable for all skin types and ages and provides natural, progressive rejuvenation without altering facial volume or expression.
Composition & Technology
Active Ingredient: Polynucleotides (2.5%)
pH Level: 6.8 – 7.5
Viscosity: 48–66 Pa·s
Recommended Needles: 2 x 30G 13 mm
Technology: PN-HPT™ (Polynucleotide High Purification Technology)
Triple Action Mechanism:
Fibroblast Stimulation: Activates fibroblast receptors, inducing transformation into myofibroblasts and promoting Type I collagen and elastin production for firmer, thicker skin.
Antioxidant Activity: Neutralizes free radicals, reducing oxidative stress and improving overall skin quality.
Deep Hydration: Binds water in the extracellular matrix to provide long-lasting iso-osmotic hydration and enhanced suppleness.
Content
1 x 1.5 ml pre-filled syringe
2 x 30G 13 mm needles
Product labels
Professional use instructions
Indications
Skin laxity and dehydration
Fine lines and dullness
Photoaged or thinned skin
Reduced elasticity and firmness
Treatment Areas
Face
Neck
Décolleté
Hands
Clinical Benefits
Stimulates deep dermal regeneration and collagen synthesis
Improves elasticity, firmness, and texture
Provides antioxidant protection and long-term hydration
Reduces fine lines and signs of photoaging
Enhances natural radiance and smoothness
Duration of Results
Visible improvements last 6–12 months, depending on patient age, skin type, and lifestyle.
Maintenance sessions every 6–9 months are recommended.
Application Protocol
Technique: Microinjections, multipoint, or linear retrograde
Sessions: 4 treatments spaced 2–4 weeks apart
Post-Treatment: Mild redness or swelling may occur; normal activities can resume immediately
Manufacturer & Regulatory Information
Manufacturer: Promoitalia Laboratories S.r.l. (Italy)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
