PLENHYAGE® XL Strong 1x2 ml
 
Product Overview
PLENHYAGE® XL Strong 1x2 ml is an advanced injectable polynucleotide-based biorevitalisation treatment developed to support skin regeneration, improve tissue quality and help restore the physiological condition of ageing or damaged skin.
 
Formulated with high-molecular-weight polymerised polynucleotides at a concentration of 2.5% (25 mg/ml), PLENHYAGE® XL Strong provides a high-strength polynucleotide treatment designed for professional aesthetic medicine.

Polynucleotides support the dermal environment by promoting fibroblast activity and helping improve hydration, elasticity and overall skin quality.
 
Unlike conventional hyaluronic acid dermal fillers, PLENHYAGE® XL Strong is not primarily intended to create volume or alter facial contours. Its action focuses on biostimulation and progressive tissue revitalisation, supporting a natural improvement in skin texture, firmness and appearance.
 
Technology & Composition
PLENHYAGE® XL Strong is based on highly purified, polymerised polynucleotides (PN) obtained from DNA of natural origin.
 
Polynucleotides act within the extracellular environment to support physiological tissue repair processes and fibroblast activity.

Their hydrophilic properties also help retain water within the treated tissue, supporting hydration and creating favourable conditions for dermal regeneration.
 
The 2.5% concentration provides a strong-dose formulation intended for areas requiring more intensive biorevitalisation and regenerative support.
 
Composition:
Polymerised Polynucleotides (PN): 2.5%
Polynucleotide concentration: 25 mg/ml
High-molecular-weight polynucleotides
Highly purified DNA-derived material
Sterile injectable gel
 
Packaging
Each package contains:
1 pre-filled syringe of 2 ml
50 mg total polynucleotides per syringe
2 sterile disposable needles
 
Indications & Treatment Areas
PLENHYAGE® XL Strong is intended for professional biorevitalisation and regenerative aesthetic protocols focused on:
Loss of skin elasticity and firmness
Reduced skin tone
Dehydrated or stressed skin
Dull and tired-looking skin
Fine lines and signs of skin ageing
Age-related deterioration in skin quality
Improvement of skin texture
Dermal revitalisation
Support of physiological tissue regeneration
 
Common treatment areas include:
Face
Neck
Décolleté
Hands
Selected body areas requiring improvement in skin quality and tissue tone
 
Clinical Benefits
High-strength 2.5% polynucleotide formulation
Supports fibroblast activity
Promotes progressive skin biorevitalisation
Supports physiological tissue regeneration
Helps improve skin elasticity and firmness
Helps improve hydration and overall skin quality
Supports improvement in skin texture and tone
Helps reduce the appearance of fine lines associated with skin ageing
Provides progressive, natural-looking skin rejuvenation
Does not act as a conventional volumising dermal filler
Suitable for professional regenerative aesthetic protocols
 
Treatment Protocol
PLENHYAGE® XL Strong is supplied in a ready-to-use pre-filled syringe and does not require reconstitution.
Before administration, the product should be prepared and handled in accordance with the manufacturer's Instructions for Use. Administration should be performed using an appropriate professional injection technique according to the treatment area, individual patient assessment and applicable clinical protocol.
 
General product information includes:
Each pre-filled syringe contains 2 ml of product.
The formulation contains 25 mg/ml of polynucleotides.
Appropriate intradermal injection techniques may be selected according to the treatment area and professional assessment.
Treatment may consist of a course of sessions followed by maintenance treatments according to the manufacturer's protocol and individual patient requirements.
Treatment intervals and the total number of sessions should be determined according to the patient's skin condition, treatment objectives and professional assessment.
 
Treatment should only be performed by appropriately qualified healthcare professionals experienced in injectable polynucleotide and skin biorevitalisation treatments.
 
Duration of Results
PLENHYAGE® XL Strong is designed to produce a progressive biorevitalising and regenerative response rather than immediate volumisation.
 
Improvements in hydration, texture, elasticity and overall skin quality develop progressively as the treated tissue responds to the polynucleotide-based treatment.
 
The duration and degree of improvement may vary according to patient characteristics, age, skin condition, treatment area, number of sessions and maintenance protocol.

A course of treatments followed by appropriate maintenance may be recommended according to the manufacturer's Instructions for Use and professional assessment.
 
Manufacturer & Regulatory Information
Manufacturer: Bioformula S.r.l.
Brand: PLENHYAGE®
Country of Origin: Italy
Product Type: Injectable Polymerised Polynucleotide (PN) Biorevitalisation Treatment
Polynucleotide Concentration: 2.5% (25 mg/ml)
Medical Device: Class III
CE Marked
Intended for professional use in accordance with the manufacturer's Instructions for Use and applicable medical device regulations.
 
For Professional Use Only
As a trusted distributor within the medical aesthetics sector, AesthiSave® emphasises that all products supplied are intended exclusively for professional use.
These treatments must only be performed by appropriately qualified healthcare professionals with suitable training and clinical experience, ensuring the highest standards of patient safety and care.