MASTELLI NEWEST 2 ml – Advanced Biorevitalization with Polynucleotides & Hyaluronic Acid
 
MASTELLI NEWEST 2 ml, developed by Mastelli S.r.l. Officina Bio-Farmaceutica (Italy), is an innovative biorevitalization gel that combines highly purified polynucleotides (PN-HPT®) with non-cross-linked hyaluronic acid and mannitol to restore skin health, elasticity, and luminosity.
It is especially effective for mature, dehydrated, or damaged skin, offering visible rejuvenation and long-term dermal repair.
 
Product Overview
MASTELLI NEWEST delivers synergistic bioreparative and hydrating effects.
Polynucleotides stimulate fibroblast activity and collagen production, while hyaluronic acid ensures deep, long-lasting hydration. Mannitol, an antioxidant, protects the skin from oxidative stress, enhancing treatment results.
This combination provides a complete solution for skin restructuring, hydration, and revitalization, particularly in cases of advanced aging or dermal damage.
 
Technology & Composition
Polynucleotides (PN-HPT®): 10 mg/ml – promotes fibroblast regeneration and collagen synthesis
Hyaluronic Acid (non-cross-linked): 10 mg/ml – provides deep dermal hydration and tissue plumping
Mannitol: Antioxidant stabilizer that protects HA from degradation
 
Mechanism of Action:
Regenerates dermal tissue
Increases elasticity and firmness
Enhances hydration and skin luminosity
Protects cells from oxidative damage
 
Packaging
1 pre-filled syringe of 2 ml
2 sterile 30G ½” needles
Product labels and professional instructions
 
Indications & Treatment Areas
MASTELLI NEWEST is indicated for:
Skin Rejuvenation: Treatment of acne scars, photoaging, and structural dermal damage
Mature or Dehydrated Skin: Improving tone, texture, and hydration
Loss of Elasticity: Increasing firmness and resilience in aging skin
 
Treatment Areas:
Face
Neck
Décolleté
Hands
 
Clinical Benefits
+39.6% improvement in skin elasticity
+51.1% increase in brightness and radiance
–17.1% reduction in wrinkle depth and skin roughness
Enhances dermal density and hydration
Reduces fine lines and photoaging signs
Provides progressive, natural-looking rejuvenation
 
Treatment Protocol
Younger Patients:
Frequency: 1 session every 14–21 days
Total: 3 sessions
Advanced Skin Aging:
Frequency: 1 session every 14–21 days
Total: 4 sessions
Injection Depth: Intradermal
Technique: Microdroplet or linear technique for even product diffusion and optimal dermal stimulation
 
Aftercare Recommendations
Avoid direct sunlight, heat, or sauna exposure for 48 hours
Use gentle skincare products and avoid peels or exfoliation for several days
Maintain adequate hydration to optimize recovery and results
 
Duration of Results
Visible improvement can be observed after the first few sessions.
Results typically last 6 to 9 months, depending on skin type, lifestyle, and follow-up treatments.
 
Manufacturer & Regulatory Information
Manufacturer: Mastelli S.r.l. Officina Bio-Farmaceutica, Sanremo, Italy
Compliance:
• CE-marked Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
 
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.