NUCLEOFILL MEDIUM 1x1.5 ml – Polynucleotide Biorestructuring for Global Skin Rejuvenation
NUCLEOFILL MEDIUM 1.5 ml is an advanced biorestructuring injectable developed by Promoitalia Laboratories (Italy), designed to improve skin elasticity, firmness, and radiance through deep biostimulation.
Formulated with high-purity polynucleotides, it works at the cellular level to stimulate fibroblast activity, enhance hydration, and combat oxidative stress, offering natural and long-lasting rejuvenation.
Product Overview
NUCLEOFILL MEDIUM represents an innovative anti-aging solution that restores the skin’s vitality by improving tissue oxygenation, density, and tone.
Its triple-action mechanism targets the dermal structure, promoting regeneration and strengthening the skin barrier.
It’s ideal for patients showing moderate signs of aging, loss of elasticity, and dull or dehydrated skin.
Composition & Technology
Active Ingredient: Highly purified polynucleotides
Concentration: 2%
Volume: 1.5 ml pre-filled syringe
Technology: PN-HPT™ (Polynucleotide High Purification Technology)
pH: 6.8 – 7.2
Viscosity: 28 – 43 Pa·s
Needles: 2 x 30G 13 mm
Triple Action Mechanism:
Fibroblast Activation: Stimulates fibroblast receptors, transforming them into myofibroblasts that produce Type I collagen and elastin, improving skin density and firmness.
Antioxidant Protection: Neutralizes free radicals and reduces oxidative stress, improving skin clarity and tone.
Iso-Osmotic Hydration: Retains moisture in the extracellular matrix, ensuring deep, long-lasting hydration and elasticity.
Content
1 x 1.5 ml pre-filled sterile syringe
2 x 30G 13 mm sterile disposable needles
Product labels
Professional instructions for use
Indications
Skin laxity and loss of firmness
Dehydrated, dull, or tired-looking skin
Fine lines and early wrinkles
Photoaging or environmental skin damage
Post-procedure skin recovery
Treatment Areas
Face
Neck
Décolleté
Hands
Clinical Benefits
Stimulates fibroblast activity and collagen synthesis
Improves skin elasticity, tone, and density
Reduces fine wrinkles and signs of aging
Restores luminosity and hydration
Provides antioxidant protection and cellular renewal
Treatment Protocol
Technique: Injection using needle or cannula (multi-point or linear retrograde technique)
Schedule:
4 sessions spaced every 2–4 weeks
Maintenance every 6–9 months depending on skin condition
Post-Treatment: Minimal downtime; slight redness or swelling may occur
Manufacturer & Regulatory Information
Manufacturer: Promoitalia Laboratories S.r.l. (Italy)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
