CROMA PolyPhil Injectable Polynucleotides 1x2 ml – Advanced Polynucleotide-Based Skin Regeneration
CROMA PolyPhil Injectable Polynucleotides 1x2 ml is an innovative injectable biostimulator developed by CROMA-Pharma GmbH (Austria).
Formulated with high-purity polynucleotides (PN-HPT™), it is designed to restore skin vitality, elasticity, and structure from within, delivering visible rejuvenation without volumization.This next-generation bioregeneration treatment activates fibroblasts, boosts hydration, and stimulates collagen and elastin synthesis, achieving progressive, natural-looking results for patients seeking regenerative improvement and enhanced skin quality.
Product Overview
PolyPhil is part of Croma’s regenerative product line that works on a cellular level to stimulate dermal renewal, tissue repair, and hydration balance.
It is particularly suitable for early signs of aging, skin laxity, and dehydration, and can be safely combined with other non-invasive aesthetic treatments.
Technology & Composition
Technology: PN-HPT™ (Polynucleotides Highly Purified Technology) — a patented purification method ensuring long-chain, intact polynucleotides with superior dermal biocompatibility and regenerative action.
Composition:
• Polynucleotides (high purity) – support cellular turnover and dermal hydration.
• Buffer and stabilizing agents – maintain isotonic and pH balance.Packaging (Content):
• 1 prefilled syringe of 2 ml
• Product labeling and instructions for professional use
Indications & Treatment Areas
Skin revitalization and hydration
Loss of firmness and elasticity
Fine lines and early wrinkles
Dull or dehydrated skin
Combination therapy: Ideal as pre-treatment or maintenance following fillers, laser, or RF procedures
Recommended Areas:
Cheeks, jawline, neck, décolleté, perioral zone, and hands.
Clinical Benefits
Activates fibroblasts to boost natural collagen and elastin
Deeply hydrates and improves skin texture
Enhances tone, firmness, and radiance
Non-volumizing: Improves skin quality without altering facial contours
Progressive and long-lasting results with minimal downtime
Treatment Protocol
Sessions: 3–4 treatments, spaced 2–3 weeks apart
Maintenance: Every 6 months or as clinically indicated
Application: Microinjections into the mid to deep dermis or subdermis
Duration: Results last up to 12 months, depending on skin condition and lifestyle factors
Manufacturer & Regulatory Information
Manufactured by CROMA-Pharma GmbH (Austria).
CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745.
ISO 13485 certified manufacturer.
Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union.
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety and patient care.
