CROMA PolyPhil Next 1x2 ml – Advanced Polynucleotide & Hyaluronic Acid Biostimulator for Mature and Photoaged Skin
CROMA PolyPhil Next 1x2 ml is an advanced injectable biostimulator developed by CROMA-Pharma GmbH (Austria), powered by PN-HPT™ (Polynucleotides Highly Purified Technology) and non-crosslinked Hyaluronic Acid.
Formulated for mature, photoaged, and environmentally damaged skin, it promotes cellular renewal, collagen synthesis, and deep dermal repair while improving hydration and elasticity without adding excessive volume.This next-generation treatment offers a biological skin rejuvenation approach for patients with visible signs of aging such as wrinkles, laxity, and dullness—restoring firmness, structure, and luminosity from within.
Product Overview
PolyPhil Next is part of CROMA’s regenerative PN-HPT™ range, optimized for advanced-age skin requiring intensive dermal restructuring.
It supports the skin’s natural healing and regenerative processes, delivering progressive, natural improvement in tone, texture, firmness, and hydration.
Technology & Composition
Technology:
PN-HPT™ (Polynucleotides Highly Purified Technology) — an advanced purification process ensuring long-chain, biocompatible nucleotides that stimulate fibroblast proliferation and promote neocollagenesis, combined with non-crosslinked Hyaluronic Acid for hydration and elasticity.
Composition:
• Polynucleotides (20 mg) – high-purity long-chain PN for deep dermal repair and fibroblast stimulation.
• Hyaluronic Acid (20 mg) – non-crosslinked HA for hydration and extracellular matrix restoration.
• Buffer solution – maintains isotonic pH balance and product stability.
Packaging
• 1 sterile vial of 2 ml
• Professional instruction leaflet and product labeling
• Single-patient use only
Indications & Treatment Areas
Indications:
• Advanced signs of aging – wrinkles, laxity, loss of density
• Photoaged and environmentally damaged skin
• Dull or uneven skin tone and texture
• Loss of hydration and elasticity
• Biological rejuvenation without volumization
Treatment Areas:
Face (cheeks, jawline, temples), neck, décolleté, hands, and other photoexposed areas.
Clinical Benefits
• Dual-action formula combining PN-HPT™ and Hyaluronic Acid
• Stimulates fibroblast activity and collagen remodeling
• Deep hydration and structural regeneration
• Improves firmness, elasticity, and overall skin vitality
• Repairs oxidative and photoaging damage
• Provides natural, progressive results with improved skin radiance
Treatment Protocol
• Sessions: 3–4 sessions spaced 2–3 weeks apart
• Maintenance: every 6–9 months, depending on skin condition
• Application: microinjections into the mid to deep dermis or subdermal plane
• Duration of results: visible improvement after 2 sessions; results last 6–12 months
Manufacturer & Regulatory Information
Manufactured by CROMA-Pharma GmbH (Austria).
CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745.
ISO 13485 certified manufacturer.
Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union.
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety and patient care.
