NUCLEOFILL MEDIUM PLUS 1x2 ml – Polynucleotide Biorestructuring Treatment for Skin Revitalization and Firmness
NUCLEOFILL MEDIUM PLUS 1x2 ml is an advanced biorestructuring injectable developed by Promoitalia Laboratories (Italy), specifically formulated to improve skin quality, elasticity, hydration, and firmness.
This innovative treatment harnesses the properties of high-purity polynucleotides to support skin regeneration, enhance tissue hydration, and improve the overall dermal environment, promoting firmer, smoother, and more revitalized skin.
Product Overview
NUCLEOFILL MEDIUM PLUS is designed to support skin biostimulation and tissue restructuring, helping improve elasticity, hydration, and the appearance of aging skin.
Its polynucleotide-based formulation supports fibroblast activity and helps maintain a favorable extracellular environment for skin renewal.
It is particularly suited to aesthetic protocols addressing skin laxity, dehydration, reduced elasticity, fine lines, and early signs of aging.
Composition & Technology
Active Ingredient: Highly purified polynucleotides (PN)
Concentration: 2% polynucleotides (20 mg/ml; subject to confirmation against the product's official IFU)
Volume: 2 ml pre-filled syringe
Technology: Highly purified polynucleotide-based biorestructuring formulation
Formulation: Sterile, biocompatible injectable gel
Mechanism of Action:
Biostimulation: Supports fibroblast activity and extracellular matrix remodeling, contributing to improved skin structure and elasticity.
Hydration & Tissue Support: Polynucleotides interact with water molecules, helping maintain dermal hydration and a favorable environment for tissue renewal.
Antioxidant Protection: Helps counteract oxidative stress and supports the skin's natural regenerative processes.
Content
1 x 2 ml pre-filled sterile syringe
Product labels
Professional instructions for use
Indications
Skin laxity and reduced firmness
Fine lines and early signs of skin aging
Dehydrated skin and reduced elasticity
Dull or tired-looking skin
Loss of skin quality associated with environmental and chronological aging
Skin revitalization and biorestructuring treatments
Treatment Areas
Face
Neck
Décolletage
Other areas where supported by the manufacturer's instructions for use
Clinical Benefits
Improves skin hydration and elasticity
Supports fibroblast activity and tissue regeneration
Enhances skin firmness and overall texture
Helps reduce the appearance of fine lines
Supports antioxidant protection and skin recovery
Promotes smoother, healthier-looking, and revitalized skin
Treatment Protocol
Technique: Administration by a qualified medical professional using the injection technique and anatomical depth specified in the manufacturer's instructions for use.
Schedule:
Initial treatment course determined according to individual skin condition and clinical assessment
Subsequent sessions based on treatment response and the manufacturer's recommended protocol
Maintenance treatments as clinically indicated
Combination Therapy: May be incorporated into broader aesthetic treatment plans, subject to clinical assessment, product compatibility, and the manufacturer's instructions.
Manufacturer & Regulatory Information
Manufacturer: Promoitalia Laboratories S.r.l. (Italy)
Compliance:
CE marking and applicable medical device classification must be verified against the specific product documentation.
Manufacturer's ISO 13485 certification status should be confirmed using current documentation.
Distribution in Spain and the European Union is subject to applicable medical device regulations and national requirements, including those overseen by AEMPS.
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
