MASTELLI PLINEST POLYNUCLEOTIDES 2 ml – Advanced Polynucleotide Skin Rejuvenation
MASTELLI PLINEST POLYNUCLEOTIDES, developed by Mastelli S.r.l. Officina Bio-Farmaceutica (Italy), is an advanced bioreparant injectable gel designed to promote skin rejuvenation, elasticity, and hydration.
Based on the patented PN-HPT® (Polynucleotide High Purification Technology), it stimulates fibroblast activity, enhancing collagen and elastin synthesis to restore skin firmness, vitality, and radiance.
Product Overview
This high-purity polynucleotide formulation delivers deep dermal bio-repair and revitalization for the face, neck, and décolleté, offering a comprehensive anti-aging effect.
By reactivating cellular metabolism, it promotes tissue regeneration, improves dermal structure, and restores a youthful glow to the skin.
Technology & Composition
Active Ingredient: High-purity polynucleotides (PN-HPT®)
Concentration: 20 mg/ml (2.5%)
Mechanism of Action: Fibroblast stimulation, collagen and elastin synthesis, and dermal matrix restoration
Key Features:
Promotes skin regeneration and elasticity
Deeply hydrates and revitalizes the dermis
Restores firmness, volume, and tone
Ensures safety and high biocompatibility through advanced PN-HPT® purification
Packaging
1 pre-filled syringe of 2 ml
2 sterile 30G ½” needles
Product labels and professional instructions
Indications & Treatment Areas
MASTELLI PLINEST POLYNUCLEOTIDES is indicated for:
Skin Rejuvenation: Improving texture, firmness, and elasticity
Preventative Anti-Aging: Maintaining youthful, hydrated skin in younger patients
Tissue Repair: Supporting recovery of photo-damaged or fatigued skin
Treatment Areas:
Face
Neck
Décolleté
Clinical Benefits
Activates fibroblasts to enhance collagen and elastin production
Improves skin tone, firmness, and elasticity
Deeply hydrates and revitalizes the dermis
Promotes natural regeneration and radiance
Suitable for preventive and corrective treatments
Treatment Protocol
Frequency: Every 14–21 days
Sessions: 3–4 treatments recommended for optimal outcomes
Maintenance: Periodic follow-ups every 4–6 months, depending on patient’s skin condition
Injection Depth: Intradermal
Technique: Microdroplet or linear threading technique for uniform distribution
Aftercare Recommendations
Avoid direct sunlight and saunas for 48 hours post-treatment
Refrain from applying makeup or harsh skincare products for 24 hours
Maintain skin hydration to enhance the regenerative process
Duration of Results
Visible improvement is typically observed after the initial treatment cycle, with results lasting 6 to 9 months depending on skin type, lifestyle, and maintenance regimen.
Manufacturer & Regulatory Information
Manufacturer: Mastelli S.r.l. Officina Bio-Farmaceutica, Sanremo, Italy
Compliance:
• CE-marked Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
