NUCLEOFILL SOFT PLUS 1x2 ml – Polynucleotide Bio-Regeneration for the Periocular Area
NUCLEOFILL SOFT PLUS 1x2 ml is an advanced bio-restructuring injectable from Promoitalia Laboratories (Italy), developed specifically for rejuvenating the delicate periocular area.
It effectively reduces under-eye puffiness, fine lines, wrinkles, and dark circles, offering a gentle and natural alternative to traditional tear trough fillers.
This treatment promotes deep hydration, regeneration, and improved elasticity in the fragile skin around the eyes.
Product Overview
Formulated with low molecular weight polynucleotides, NUCLEOFILL SOFT PLUS acts through cellular stimulation, tissue oxygenation, and deep hydration.
It revitalizes the skin’s structure, enhances microcirculation, and restores a youthful appearance without adding volume.
It can also be used before or after procedures such as blepharoplasty or laser treatments to accelerate recovery and enhance tissue regeneration.
Composition & Technology
Active Ingredient: Low molecular weight, highly purified polynucleotides (PN)
Concentration: 2.5%
Volume: 2 ml pre-filled syringe
Technology: PN-HPT™ (Polynucleotide High Purification Technology)
Needles: 2 x 30G ½” disposable sterile needles
Triple Action Mechanism:
Cellular Biostimulation: Activates fibroblast receptors, promoting collagen and elastin synthesis for improved dermal density and firmness.
Tissue Repair & Oxygenation: Enhances cell turnover and microcirculation, helping reduce puffiness and under-eye shadows.
Deep Hydration: Retains water in the extracellular matrix for long-lasting moisture and improved elasticity.
Content
1 x 2 ml pre-filled sterile syringe
2 x 30G ½” disposable sterile needles
Product labels
Professional instructions for use
Indications
Under-eye puffiness
Fine lines and wrinkles
Dark circles
Periocular skin laxity and dullness
Treatment Areas
Under-eye area
Crow’s feet
Periocular region
Clinical Benefits
Reduces puffiness and dark circles
Smooths fine lines and wrinkles
Restores elasticity and firmness
Improves tone, texture, and hydration
Enhances tissue recovery before or after surgical or laser procedures
Duration of Results
Results typically last 6 to 9 months, depending on individual factors such as skin type and age.
A course of 2–3 sessions spaced 2–3 weeks apart is recommended, with maintenance every 6 months.
Application Protocol
Injection Depth: Superficial dermis of the periocular area
Technique: Microinjection or multi-point technique using supplied 30G ½” needles
Post-Treatment: Minor redness or swelling may occur; normal activities can resume within hours
Manufacturer & Regulatory Information
Manufacturer: Promoitalia Laboratories S.r.l. (Italy)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
