aesPlla® 365 mg 1 Vial (5 ml)  

Product Overview

aesPlla® 365 mg is an advanced Poly-L-Lactic Acid (PLLA) injectable collagen biostimulator developed by Oreon Life Science for the gradual restoration of facial volume and the correction of facial wrinkles and folds. Rather than providing immediate volumisation alone, aesPlla® stimulates the body's natural collagen production, delivering progressive, natural-looking rejuvenation with long-lasting structural support.  

Designed for professional aesthetic practitioners, aesPlla® is indicated for the correction of shallow to deep nasolabial fold contour deficiencies, facial wrinkles, and age-related volume loss. Clinical improvements typically begin to appear from approximately 4 weeks after treatment, with results that may last more than 2 years and up to 3 years, depending on the individual patient and treatment protocol.  

Technology & Composition

aesPlla® utilises Poly-L-Lactic Acid (PLLA), a synthetic, biocompatible and biodegradable polymer that has been safely used in medical applications for more than two decades, including absorbable surgical sutures. Following injection, PLLA microparticles stimulate fibroblast activity, promoting neocollagenesis and progressively restoring dermal structure and volume.  

Composition:

• Poly-L-Lactic Acid (PLLA)

• Sodium Carboxymethylcellulose

• Mannitol  

Packaging

Each package contains:

• 1 sterile vial

• 365 mg lyophilised powder (5 ml presentation after reconstitution)  

Indications & Treatment Areas

aesPlla® is indicated for:

• Facial volume restoration

• Shallow to deep facial wrinkles

• Nasolabial folds

• Marionette lines

• Cheek augmentation

• Temple hollowing

• Jawline definition

• Sagging jowls

• Deep dermal contour deficiencies

• Selected atrophic scars  

Clinical Benefits

• Stimulates natural collagen production

• Progressive and natural-looking facial rejuvenation

• Restores facial volume gradually

• Improves skin firmness and elasticity

• Softens moderate to severe facial wrinkles

• Long-lasting collagen remodelling

• Biocompatible and biodegradable PLLA formulation

• No pre-treatment allergy testing required

• Results may last up to 3 years following an appropriate treatment protocol  

Treatment Protocol

aesPlla® must be reconstituted according to the manufacturer's Instructions for Use prior to administration.

General manufacturer recommendations include:

• Reconstitute with 5 ml sterile Water for Injection (WFI).

• Allow appropriate hydration prior to treatment according to the manufacturer's protocol.

• Use within 72 hours after reconstitution.

• Inject using appropriate deep dermal or subdermal techniques according to the treatment area and practitioner experience.

Treatment should only be performed by healthcare professionals experienced in PLLA-based collagen stimulators.  

Duration of Results

Initial collagen stimulation generally becomes clinically visible from approximately 4 weeks following treatment.

Results continue to improve progressively as new collagen is produced and may last more than 24 months and up to 3 years, depending on patient characteristics, treatment protocol and lifestyle factors.  

Manufacturer & Regulatory Information

• Manufacturer: Oreon Life Science Co., Ltd.

• Country of Origin: South Korea

• Product Type: Injectable Poly-L-Lactic Acid (PLLA) Collagen Biostimulator

• Medical Device: CE Marked

• Manufactured under internationally recognised quality management standards including ISO 13485, in accordance with applicable medical device regulations.  

For Professional Use Only

As a trusted distributor within the medical aesthetics sector, AesthiSave® emphasises that all products supplied are intended exclusively for professional use.

These treatments must only be performed by appropriately qualified healthcare professionals with suitable training and clinical experience, ensuring the highest standards of patient safety and care.