RESTYLANE® DEFYNE™ - 1x1 ml – Dynamic Filler for Deep Wrinkle Correction and Facial Harmony
RESTYLANE® DEFYNE™ 1x1 ml, developed by Galderma Laboratories, is an advanced hyaluronic acid-based dermal filler formulated to correct moderate to deep facial wrinkles and enhance facial balance.
This filler uses XpresHAn™ Technology, a next-generation cross-linking process that provides both structure and flexibility, allowing natural facial expressions with long-lasting results.
Infused with 0.3% lidocaine, it ensures a comfortable and smooth treatment experience for patients.
Product Overview
Restylane® Defyne™ is specifically designed for dynamic facial areas, where expression and movement are key.
It restores volume and smooths deep wrinkles, such as nasolabial folds and marionette lines, while maintaining natural facial dynamics and flexibility.
This makes it an excellent choice for patients seeking natural rejuvenation without stiffness or overcorrection.
Composition & Technology
Active Ingredients:
Cross-linked Hyaluronic Acid (HA): 20 mg/ml – of non-animal origin
Lidocaine Hydrochloride: 0.3% – provides local anesthesia and improves comfort during injection
Technology:
XpresHAn™ Technology:
Exclusive to Galderma Laboratories, this patented process balances elasticity and support, creating a filler that moves naturally with facial expressions.
It delivers natural definition, flexibility, and long-lasting results in dynamic areas of the face.
Packaging
1 x 1 ml prefilled glass syringe
Sterile needles
Product labels
Professional user instructions
Indications & Treatment Areas
Restylane® Defyne™ is indicated for moderate to deep wrinkles and for improving facial contours and balance, especially in areas of high mobility.
Nasolabial folds: smooths deep lines between the nose and mouth
Marionette lines: reduces creases extending from the mouth corners to the chin
Deep wrinkles or folds: fills and smooths visible creases on the lower face
Clinical Benefits
Restores volume and smooths deep wrinkles
Maintains natural facial movement and expression
Enhances harmony and contour of the lower face
Comfortable treatment with lidocaine for reduced pain and swelling
Long-lasting correction with smooth, flexible results
Treatment Protocol
Injection Depth: Medium to deep dermis
Technique: Linear retrograde or multi-point injection technique
Post-Treatment: Minor redness or swelling may appear and typically resolves within 24–48 hours
Maintenance: Follow-up treatments every 9–12 months for sustained results
Duration of Results
Results typically last 9–12 months, depending on patient age, skin condition, lifestyle, and treatment area.
Manufacturer & Regulatory Information
Manufacturer: Galderma Laboratories (Sweden)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.
