RESTYLANE® REFYNE™ - 1x1 ml – Dynamic Filler for Natural Facial Expression and Smooth Correction
 
RESTYLANE® REFYNE™ 1x1 ml, developed by Galderma Laboratories, is a premium hyaluronic acid-based dermal filler designed to smooth moderate wrinkles and folds while preserving natural facial expressions.
It integrates smoothly into the skin for flexible, natural results, making it ideal for dynamic facial areas.
Enhanced with 0.3% lidocaine, it provides a more comfortable treatment experience by reducing pain during injection.
 
Product Overview
Restylane® Refyne™ offers a refined balance between support and elasticity, ideal for maintaining facial expressiveness while improving skin smoothness.
This filler effectively targets nasolabial folds, marionette lines, and other moderate wrinkles, providing subtle yet visible rejuvenation without stiffness or overcorrection.
Its innovative formulation ensures natural flexibility, making it particularly suitable for active, expressive facial areas.
 
Composition & Technology
Active Ingredients:
Cross-linked Hyaluronic Acid (HA): 20 mg/ml – of non-animal origin
Lidocaine Hydrochloride: 0.3% – for local anesthesia and improved patient comfort
Technology:
OBT™ (Optimal Balance Technology™):
Developed by Galderma Laboratories, OBT™ technology optimizes the cross-linking structure of HA to balance flexibility and support.
It allows the filler to move naturally with facial expressions, ensuring smooth, dynamic, and natural-looking results.
 
Packaging
1 x 1 ml prefilled glass syringe
Sterile needles
Product labels
Professional user instructions
 
Indications & Treatment Areas
Restylane® Refyne™ is indicated for smoothing moderate wrinkles and restoring facial balance while preserving natural movement.
It is injected into the mid-to-deep dermis, providing flexible yet durable correction.
Nasolabial folds (smile lines): Smooths moderate to deep wrinkles
Marionette lines: Softens folds running downward from the mouth
Moderate facial wrinkles: Restores skin smoothness while maintaining natural dynamics
 
Clinical Benefits
Smooths moderate facial wrinkles and folds
Preserves natural expression and movement
Flexible, elastic formulation for dynamic areas
Long-lasting, natural results
Comfortable treatment experience due to lidocaine
 
Treatment Protocol
Injection Depth: Mid-to-deep dermis
Technique: Linear retrograde or cross-hatching technique depending on area
Post-Treatment: Minor swelling or redness may occur, typically resolving within 24–48 hours
Maintenance: Recommended re-treatment every 9–12 months to sustain results
 
Duration of Results
Clinical effects last approximately 9–12 months, depending on metabolism, lifestyle, and the area treated.
 
Manufacturer & Regulatory Information
Manufacturer: Galderma Laboratories (Sweden)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
 
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.