RADIESSE® 1.5ML – Collagen-Stimulating Filler for Contouring and Rejuvenation
 
RADIESSE® 1.5ML is an advanced Calcium Hydroxylapatite (CaHA) dermal filler specifically designed for facial contouring, deep wrinkle correction, and long-lasting skin rejuvenation.
This non-lidocaine version allows full control for practitioners preferring customized anesthesia application, while delivering the same immediate and regenerative effects.
Its unique composition combines CaHA microspheres suspended in a biodegradable gel carrier, providing instant volume restoration and long-term collagen stimulation for natural, firm, and youthful skin.
 
Product Overview
RADIESSE® 1.5ML restores lost volume and defines facial contours with precision.
Upon injection, the gel carrier offers immediate lifting, while CaHA microspheres stimulate fibroblasts to produce new collagen and elastin, resulting in long-lasting firmness and improved skin texture.
This dual mechanism ensures both correction and regeneration, offering a natural rejuvenation effect that continues to improve over time.
 
Composition & Technology
Active Ingredients:
Calcium Hydroxylapatite (CaHA) Microspheres (25–45 µm) – Biocompatible and biodegradable, these provide a structural framework and stimulate natural collagen production.
Gel Carrier: Water-based, biodegradable gel (70% water, 30% glycerin and sodium carboxymethylcellulose) that ensures smooth injectability and immediate volumizing.
Mechanism of Action:
Instant volumization from the gel matrix.
Collagen and elastin synthesis stimulated by CaHA microspheres.
Technology:
Patented CaHA suspension system for controlled degradation and predictable biostimulation.
Formulation Type:
Injectable implant for deep dermal and subdermal application.
 
Content
1 x 1.5 ml pre-filled syringe of RADIESSE® (without lidocaine)
Product labels
Professional use instructions
 
Indications
Deep wrinkle and fold correction (nasolabial folds, marionette lines)
Facial contouring and enhancement of chin and jawline definition
Restoration of cheek volume and midface support
Profile balancing and rejuvenation
Improvement of skin density, tone, and firmness
 
Treatment Areas
Jawline and chin
Cheeks
Nasolabial folds
Marionette lines
Mouth corners
 
Clinical Benefits
Immediate correction of deep wrinkles and folds
Defines and reshapes facial contours
Stimulates natural collagen and elastin production
Improves skin firmness and elasticity
Provides a lifting and tightening effect
Natural-looking, long-lasting results (12–18 months)
Non-surgical and minimal downtime treatment
 
Treatment Protocol
Administration: Must be performed by a licensed medical professional.
Injection Depth: Deep dermis or subdermal plane, depending on the treatment area.
Procedure: Area may be numbed with topical anesthetic before injection.
Post-Treatment: Mild swelling or redness may occur, resolving within 24–48 hours.
Maintenance: Touch-up sessions may be scheduled to sustain volume and skin quality.
 
Manufacturer & Regulatory Information
Manufacturer: Merz Aesthetics GmbH (Germany)
Compliance:
• CE-marked Class III Medical Device under EU Regulation (MDR) 2017/745
• ISO 13485 certified manufacturer
• Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
 
For Professional Use Only:
As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use.
We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.