MASTELLI NEWEST 2 ml – Advanced Biorevitalization with Polynucleotides & Hyaluronic Acid
 
MASTELLI NEWEST 2 ml, developed by Mastelli S.r.l. Officina Bio-Farmaceutica (Italy), is an innovative biorevitalization gel that combines highly purified polynucleotides (PN-HPT®) with non-cross-linked hyaluronic acid and mannitol to restore skin health, elasticity, and luminosity. It is especially effective for mature, dehydrated, or damaged skin, offering visible rejuvenation and long-term dermal repair.
 
Product Overview
 
MASTELLI NEWEST delivers synergistic bioreparative and hydrating effects. Polynucleotides stimulate fibroblast activity and collagen production, while hyaluronic acid ensures deep, long-lasting hydration. Mannitol, an antioxidant, protects the skin from oxidative stress, enhancing treatment results.
 
This combination provides a complete solution for skin restructuring, hydration, and revitalization, particularly in cases of advanced aging or dermal damage.
 
Technology & Composition
 
 
 
Polynucleotides (PN-HPT®): 10 mg/ml – promotes fibroblast regeneration and collagen synthesis
 
 
Hyaluronic Acid (non-cross-linked): 10 mg/ml – provides deep dermal hydration and tissue plumping
 
 
Mannitol: Antioxidant stabilizer that protects HA from degradation
 
 
Mechanism of Action:
 
 
 
Regenerates dermal tissue
 
 
Increases elasticity and firmness
 
 
Enhances hydration and skin luminosity
 
 
Protects cells from oxidative damage
 
 
Packaging
 
 
 
1 pre-filled syringe of 2 ml
 
 
2 sterile 30G ½” needles
 
 
Product labels and professional instructions
 
 
Indications & Treatment Areas
 
MASTELLI NEWEST is indicated for:
 
 
 
Skin Rejuvenation: Treatment of acne scars, photoaging, and structural dermal damage
 
 
Mature or Dehydrated Skin: Improving tone, texture, and hydration
 
 
Loss of Elasticity: Increasing firmness and resilience in aging skin
 
 
Treatment Areas:
 
 
 
Face
 
 
Neck
 
 
Décolleté
 
 
Hands
 
 
Clinical Benefits
 
 
 
+39.6% improvement in skin elasticity
 
 
+51.1% increase in brightness and radiance
 
 
–17.1% reduction in wrinkle depth and skin roughness
 
 
Enhances dermal density and hydration
 
 
Reduces fine lines and photoaging signs
 
 
Provides progressive, natural-looking rejuvenation
 
 
Treatment Protocol
 
Younger Patients:
 
 
 
Frequency: 1 session every 14–21 days
 
 
Total: 3 sessions
 
 
Advanced Skin Aging:
 
 
 
Frequency: 1 session every 14–21 days
 
 
Total: 4 sessions
 
 
Injection Depth: Intradermal Technique: Microdroplet or linear technique for even product diffusion and optimal dermal stimulation
 
Aftercare Recommendations
 
 
 
Avoid direct sunlight, heat, or sauna exposure for 48 hours
 
 
Use gentle skincare products and avoid peels or exfoliation for several days
 
 
Maintain adequate hydration to optimize recovery and results
 
 
Duration of Results
 
Visible improvement can be observed after the first few sessions. Results typically last 6 to 9 months, depending on skin type, lifestyle, and follow-up treatments.
 
Manufacturer & Regulatory Information
 
Manufacturer: Mastelli S.r.l. Officina Bio-Farmaceutica, Sanremo, Italy Compliance: • CE-marked Medical Device under EU Regulation (MDR) 2017/745 • ISO 13485 certified manufacturer • Distributed under compliance with AEMPS (Agencia Española de Medicamentos y Productos Sanitarios) in Spain and the European Union
 
For Professional Use Only:As trusted distributors and providers of aesthetic medicine, Aesthisave® emphasizes that our products are strictly for professional use. We insist that these treatments be administered only by trained and medically qualified personnel, ensuring the highest standards of safety, precision, and patient care.